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Defined in the DSM-5, it includes behaviors such as difficulty controlling use, cravings, and continued use despite health risks like cardiovascular disease or respiratory problems

Ethics statements Patient consent for publication Ethics approval This study does not involve human participants

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Although we detected R2-mediated integration into episomal and genomic rDNA in transient assays and callus tissue, we did not recover regenerated plants harboring stable rDNA insertions

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