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Reducing nicotine levels in cigarettes could complement these strategies and bring us one step closer to a society free of tobacco-related disease and death. Cigarette smoking remains the leading cause of preventable disease and death in the United States, responsible for an estimated 480,000 deaths each year

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But we know from a long history of drug prohibition - like alcohol prohibition in the 1920s - that banning or restricting vaping could actually do more harm than good

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Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request

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