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The likelihood of developing coronary heart disease and pancreatic cancer is equivalent to a non-smoker

Presence of WMH was determined as Fazakas grade 1

Possible biomarkers The researchers conclude that exposure to second-hand smoke was associated with changes in protein expression that are linked to the response to toxic elements in the blood, systemic inflammation/autoimmunity, and blood vessel diseases. Long-term follow-up to detect changes over time would provide more answers about how second-hand smoke affects health in the long term

A challenge of observational studies is potential confounding, because without randomization, certain factors (confounders) may be systematically and unequally distributed across e-cigarette users and non-users

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