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In the lungs, MMP12 is expressed and secreted by both alveolar macrophages and bronchial epithelial cells, and plays a key role in airway remodeling, a feature of severe asthma [30, 31]

How Your Lungs are Designed to Work (The Healthy Baseline) To grasp the damage, we must first appreciate the elegant design of a healthy respiratory system

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By 1990 this had fallen to just under a third