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Recurrent lung infections can also be a sign of lung cancer, which is the leading cause of cancer death among smokers

Carcinogenesis 23:19792004 Liu Z, Muehlbauer KR, Schmeiser HH, Hergenhahn M, Belharazem D, Hollstein MC (2005) p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors

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This metabolite has a longer half-life and also binds to opioid receptors, although with less efficacy than buprenorphine itself