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[11] End-stage [edit] In severe cases of the disease, the following signs and symptoms may be present: [8] Blood clots in the veins, which may cause thrombophlebitis Disseminated intravascular coagulation, a disorder causing severe bleeding in many body organs Jaundice, or yellowing of the eyes and skin Low blood sugar Pleural effusion Pulmonary embolism, or blood clots in the arteries of the lungs Severe ascites If a mesothelioma forms metastases, these most commonly involve the liver, adrenal gland, kidney, or other lung