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10.1038/nrcardio.2016.179 5

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The latest study found that overexpression of mesencephalic astrocyte-derived neurotrophic factor (MANF), a secreted protein belonging to growth factors, ameliorated defective mitophagy and reduced cGAS-STING activation, which inhibited renal interstitial fibrosis (Zhu et al., 2022)

Risk Factors for SUD Numerous factors elevate the risk of developing disorders associated with substance misuse, among them are an individuals genetic makeup, their surrounding environment, and various developmental aspects