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Macrophages typically exist in two subsets: classically-activated macrophages (M1) or alternatively-activated macrophages (M2) [112]

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These premises include: relevant trade premises (those that are only accessible to people that work in the tobacco trade) specialist tobacconists bulk tobacconists (including duty-free tobacco areas) In England, Wales and Northern Ireland, we propose to maintain current exemptions for tobacco products for relevant trade premises and specialist tobacconists