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The cost of preparing a PMTAoften millions of dollars per producteffectively excluded most small companies from the legal market

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Here is that evidence: e-cigarette use involves the inhalation of toxic substances and is associated with poisoning, lung injury and burns nicotine e-cigarettes can cause dependence or addiction in non-smokers young non-smokers who use e-cigarettes are more likely than non-users to initiate smoking and become regular smokers e-cigarettes do not result in reduced harm if users continue to smoke (which most do)