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molecular signals driven by epithelium/immune cells (TGF-, STAT3, ROS, miRNA, etc.) not only directly promote the functional activation of smooth muscle and fibroblasts that leads to fibrosis, but also exacerbate tissue hypoxia and progressive injury by altering tissue mechanics and microvascular blood supply

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However some are made from meerschaum, which is a mineral deposit that is carved and later polished with hardened bees wax