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Both cigarette smoking and e-cigarette vaping are known to promote endothelial dysfunction, which is the inability of big blood arteries to open sufficiently to give enough blood to the heart and other tissues

Chen X, Wen W, Anstey KJ, Sachdev PS

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This observation was confirmed using other nAChR agonists, showing that receptor activation at the mitochondrial membrane activates signaling pathways similar to receptor activation at the cell membrane, resulting in inhibition of calcium-induced, mitochondria-driven apoptosis (Gergalova et al

She says if they don't quit immediately, they'll never be able to stop