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A typical chancre appears as a painless, indurated, shallow, and clean-based ulcer with raised edges

FDAs review of modified risk products is intended to ensure that adult users have clear, science-based information about the relative harms of tobacco products, so they can make informed choices, said Bret Koplow, acting director of the FDAs Center for Tobacco Products

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In cases of chronic sinusitis or structural problems, endoscopic sinus surgery may be needed to open nasal passages

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