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Blockage of vascular supply to the legs may lead to gangrene and amputation

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A 2007 University of Michigan Health System study reported that 75 percent of women smokers say they would be unwilling to gain more than five pounds while quitting and nearly half said they would not tolerate any weight gain at all

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These contribute to oxidative stress and damage epithelial cells by inducing peroxidation of lipids and other cell membrane constituents, activate oxidative-sensitive cellular pathways, and induce DNA damage [35]