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The researchers hypothesized that nicotine might act on these pacemaker neurons so as to increase the ratio of glutamate to GABA in the VTA

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The study was published online on December 17 in the Journal of Psychopharmacology

Mendelian randomisation of effect of smoking on bipolar disorder When comparing the current findings to those of a previous study evaluating the relationship between smoking and other severe mental illness, Reference Wootton, Richmond, Stuijfzand, Lawn, Sallis and Taylor12 the effect sizes we found are comparable to those testing lifetime smoking and smoking initiation as a risk factor for schizophrenia and major depressive disorder

But what exactly does it do