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The 1964 report of the Surgeon Generals Advisory Committee marks the beginning of a significant shift in public attitudes about smoking

In Chapter 3 of Monograph 22: A Socioecological Approach to Addressing Tobacco-Related Health Disparities, titled Genetics, Physiological Processes, and Tobacco-Related Health Disparities, genetic variations in the CHRNA5-CHRNA3-CHRNB4 gene cluster are identified as being strongly linked to nicotine dependence

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This inflammation causes the blood vessels in your head to constrict and make it harder for oxygen to reach your brain tissue, leading to headaches

Of this, 2.4billion falls on the NHS, 1.19billion falls on the social care system, and over 13billion is lost in productivity costs from tobacco-related lost earnings, unemployment and premature death