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The most important is the classic pathway, where the hydrolysis of NAPEs occurs by NAPE-specific phospholipase D (NAPE-PLD)

Furthermore, these vapours could elicit persistent behavioural changes later in adulthood.88 A recent study focused on the new device subtype of the heat-not-burn tobacco cigarettes (IQOS in particular), also casting shadows on the potential toxic effect of these products