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Hypoxia, in turn, leads to the HIF-1-dependent upregulation of methionine adenosyltransferase 2A, which is an enzyme that synthesizes S -adenosylmethionine, a major biological methyl donor critical for DNA methylation processes (Liu et al., 2011)

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He was wandering up and down, endlessly striking matches to light the pipe he was never without, and talking through it, and round it, and sometimes to it, and to me, and frequently over my head, about that long-awaited next book

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