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[46] European Union standards are published in the EU Tobacco Products Directive

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Details for each outcome on the search string used in the systematic review approach, refined inclusion and exclusion criteria, data extraction template and PRISMA diagram are given in Supplementary Information 1

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Based upon our rigorous scientific review, in this instance, the strength of evidence of benefits to adult smokers from completely switching to a less harmful product was sufficient to outweigh the risks to youth, said Matthew Farrelly of FDAs Center for Tobacco Products.