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Histopathology revealed microscopic papillomas in some oral mucosa tissues of tobacco or gutka -treated animals.[] Topical application of an extract of Banarasi chewing tobacco extract to the cheek pouch mucosa of Syrian golden hamsters induced leukoplakia only.[] However, in another study, forestomach tumors developed the following application of snuff to the hamster cheek pouch mucosa.[] Skin papillomas were induced following application of black or brown masheri extract to the back skin of nude Swiss mice,[] although topical application of a black masheri extract did not induce skin tumors in Swiss mice

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Availability risks also appear when blend stability requirements tighten, reducing the ability to sustain flavor continuity at scale and slowing repeat purchase behavior