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While Constantine modified John in a number of ways, most notably changing him from English to American, his chain-smoking is a core aspect of his comic book backstory that the film made into a tool of his character development

The development of NAFLD has serious clinical complications because of its potential progression from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma

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ISBN 978-0-415-30691-1