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Since scientists have shown that a drug becomes more addictive when it is delivered to the brain more rapidly, freebase nicotine levels in cigarette smoke thus are at the heart of the controversy regarding the tobacco industrys use of additives like ammonia and urea, as well as blending choices in cigarette design. A 1997 study led by Prof Pankow linked ammonia additives with increased freebase nicotine levels in cigarettes

Most people are able to associate diseases such as heart disease and lung cancer with cigarette smoking, while the adverse effects of smokeless tobacco and e-cigarettes may seem comparatively benign to them