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The following must be observed: Daily use of tobacco for at least several weeks Abrupt cessation of tobacco use, or reduction in the amount of tobacco used, causing clinically significant distress or impairment in social, occupational, or other important areas of functioning, followed within 24 hours by four or more of the following signs/symptoms: Irritability, frustration, or anger Anxiety Difficulty concentrating Increased appetite Restlessness Depressed mood Insomnia Credits: AsapSCIENCE Tobacco Use Disorder To be diagnosed with tobacco use disorder in accordance with the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, a problematic pattern of tobacco use leading to clinically significant impairment or distress must be observed, as manifested by at least two of the following, occurring within a 12-month period: Tobacco is often taken in larger amounts or over a longer period than was intended