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In T-B2B cells, acute WCSE exposure resulted in the constitutive upregulation of NRF2 and NQO1 independent of KEAP1 expression, suggesting that a KEAP1-independent mechanism contributes to the enhanced NRF2 stability in T-B2B cells (Fig

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It was found that the OPFRs only increased the level of ROS and methemoglobin at very high concentrations: at 500 g/mL, they were found to induce morphological changes and ultimately cause lytic cell death and PS externalization