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Research by the Centers for Disease Control and Prevention suggests that nicotine may be as addictive as heroin, cocaine, and alcohol

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Exploratory mixed effects models (see Supplemental Material) were used, where appropriate, to compare urinary concentrations of CBD, 7-OH-CBD or 7-CBD-COOH (I) between routes of administration or (II) oral formulations with the factors of dose condition and time post-administration (baseline and 16 time points) and (III) between fasted states with the factors of dose condition (overnight fasting and standard low-fast breakfast) and time post-administration (baseline and 16 time points)

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