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The finding is particularly worrisome because "the tobacco industry views women as its growth market," according to a commentary published along with the study

This effect is best understood in the context of gene promoters where DNA methylation can impair physical binding of transcription enhancers and promote the recruitment of methyl-CpG-binding domain proteins that increase chromatin condensation and thus decrease the DNA accessibility for the transcriptional machinery (Portela and Esteller, 2010)

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