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In addition, mesenchymal markers (S100A4, N-cadherin, Vimentin, and -SMA proteins) and ECM proteins (type I collagen and fibronectin) were also found increased in smokers and COPD

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Former smokers, also at 25% of the population, had an RR of 3.4, while alcohol abusers comprised the remaining 5% and had an RR of 4.0