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In addition, concerns have been raised that oral nicotine pouch manufacturers are mimicking marketing tactics used by e-cigarette companies to attract young people, including influencer marketing, appealing flavors, and sponsored events

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Mesenchymal stromal cells, which form the structural and signaling backbone of the stem cell niche, are decreased in number and function, and exhibit dysregulated signaling that can paradoxically promote progenitor proliferation despite reduced reserve