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Niacin is also unsafe for certain groups, including people: with peptic ulcers with diabetes or metabolic syndrome with liver disease with arterial bleeding who are pregnant or chestfeeding Because of these drawbacks, doctors may recommend other drugs such as statins, ezetimibe, or PCSK9 inhibitors before suggesting niacin therapy

Smoking during pregnancy can cause disability and may require great efforts for correction

1 2 Miles 2001, p

This is also when physical cravings reach their peak

Ultimately its just a thing that is there without any fanfare or deeper presence - I bet when it was launched there was little relief or anxiety about its potential or performance

This is the major cause of cancer