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These websites were selected as more than 90% of their total online traffic during 2021 originated in Europe and there was no major concentration coming from a specific country on the continent, which indicates diversity in the location of the users visiting these online retailers

Additionally, while we observed a positive relationship between elevated serum cotinine levels and total testosterone levels, it remains unclear whether this association is reversible and if testosterone levels decrease upon smoking cessation

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Thus, only using biological measures (cotinine analysis) that assess physical dependence does not capture all aspects of dependence 22