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For the present study, we conducted two additional sensitivity analyses to examine how the shape of the risk curves was impacted by applying a monotonicity constraint and trimming 10% of data

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We found that, due to small numbers of studies, inconsistency in the data, small effect sizes or a combination of these reasons, seven outcomes for which some previous research had found an association with smoking did notunder our meta-analytic framework and conservative approach to interpreting the datahave evidence of an association

Certain diseases, such as ischemic heart disease (heart attacks and related coronary artery disease), stroke, chronic lung disease and lung cancer, have been clearly linked to smoking and were found to be the cause of death in approximately 60% of the smokers in these studies

Statistical analysis Analyses were carried out using R v.3.6.3, Python v.3.8 and Stata v.16