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Fed Regist 77:2003420037 Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J, Prokopowicz A, Jablonska-Czapla M, Rosik-Dulewska C, Havel C, Jacob P 3rd, Benowitz N

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Furthermore, most studies have been conducted in two-dimensional culture systems or animal models, which cannot fully recapitulate the structural and cellular complexity of the human airway epithelium