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P Natal Acad Sci USA 107: 46184622

PLoS ONE 9 , e102943 (2014)

Numerous factors may have affected that decline, e.g., on-line sales for which use taxes were never paid, loss of wealth associated with the housing crises, consumers paying down debt, the aging of the population, the changing income distribution

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Smoking cessation and harm reduction E-cigarettes are widely used as a smoking cessation tool: 32.4% of Canadian smokers used e-cigarettes for this purpose in 2017,[2] and the UK National Health Service officially recommends e-cigarettes as a smoking cessation aid.[18] Though older studies[19-21] have shown that e-cigarettes are not superior to traditional nicotine replacement therapy (NRT) for smoking cessation, more recent randomized controlled trials have shown e-cigarettes to be superior to NRT [Table 1]

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