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These withdrawal symptoms include negative a ect such as irritability, frustration or anger, anxiety, dysphoric or depressed mood, restlessness, di culty concentrating, insomnia, decreased heart rate, and increased appetite.6 Other possible symptoms can include constipation, cough, dizziness, increased dreaming, and mouth sores.35 Withdrawal symptoms, with the exception of weight, peak during the rst week of abstinence and then gradually drop to baseline levels by 24 weeks,3537 although further studies have shown withdrawal to be persistent and elevated for several months after quitting.38,39 However, weight might increase over the course of 6 months, and then decrease or become sustained.40 Studies have also shown individual variations in the intensity, slope, and variability of symptoms.41 Symptoms of great intensity, positive slope, and variability predict relapse to smoking42,43 and those of craving and negative a ect were the most likely to be associated with relapse.44,45 Withdrawal symptoms can make abstaining smokers more reactive to environmental events that engender emotional reactions.46 In addition to the physiological basis for addiction, behavioural or learning factors also sustain addiction

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