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A report examining PMI data on Sprague Dawley rats exposed to IQOS smoke or CS for 90 days observed increased markers of acute hepatotoxicity, including liver weight and alanine aminotransferase, in the IQOS-exposed group 54

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"Even if many people don't realize it: Simply 'dropping' cigarettes, garbage or other items on the sidewalk, the street or in the park is not a trivial offense and significantly impairs the quality of life," explains Frank Weber, Head of the Public Order Office of the City of Offenbach

45 Also in the US, counties with higher tobacco retailer availability were shown to have greater chronic obstructive pulmonary disease (COPD)-related discharges, hospital stays, and financial costs, suggesting that policies that reduce tobacco retailer availability could reduce COPD-related burdens