is tobacco the most addictive substance 19 Substances and Their Risks Comparative risk assessment of alcohol,
Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach Scientific Reports Nicotine is one of the most addictive substances available. According to The National Institute on Drug Abuse NIDA, it changes the brain's reward pathways, making the body depend on it to Why don't smokers quit? ASH > Action on Smoking & Health The 5 Most Physically Addictive Substances Infographic Evolve Indy 5 Most Addictive Drugs of Abuse in 2026: Evidence Based Rankings Global Women's Network Tobacco Nicotine Rutgers Addiction Research Center (RARC)
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