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Few studies even looked at gender, she said, and those that did either showed no difference or when there was a difference, women did worse than men. The ineffectiveness of these current medications and the smoking-stress connection in women suggests the need for a different treatment approach, McKee said

Compared with traditional cigarettes, studies have shown that kreteks contain significantly higher levels of nicotine, carbon monoxide, and tar, as well as several more chemicals, thus making them much more harmful overall

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The Health Consequences of Smoking: A Report of the Surgeon General, 2004.