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Overall, 97 (94%) of participants achieved an SVR12.[22] Sofosbuvir-Velpatasvir (ASTRAL Trials) : In a subset analysis of the phase 3 ASTRAL trials, investigators compared treatment response to sofosbuvir-velpatasvir in persons receiving opioid substitution therapy during treatment (n = 51) compared with those who were not receiving opioid substitution therapy (n = 984).[26] Receipt of opioid substitution therapy did not impact treatment responses

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