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The path to this achievement was a difficult one and the road ahead to effective implementation may be very bumpy as well

Additionally, patients were discharged due to missed or rescheduled appointments [22]

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This is emphasized by the fact that endogenous-estrogen, 17-estradiol (E2), the most potent human estrogen, affects almost every tissue or organ system, including the heart and blood vessels where it is linked in premenopausal women to NO production, blood pressure lowering actions, and multiple cardiovascular protective effects [13]