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This is why the agencys PMTA review focuses not only on things that come with the product itself like ingredients, toxicology, manufacturing, packaging and labeling but also on the net public health impact of individual products at a population level, according to the FDA spokesperson

OBeirne SL, Kikkers SA, Oromendia C, Salit J, Rostmai MR, Ballman KV, et al

Nicotine use has long-term effects like: Irritability Appetite increase Cravings for tobacco products Problems focusing Withdrawal symptoms Anxiety Inability to control addiction Possible overdose, although uncommon Individuals can smoke anywhere from 3 cigarettes to a pack or more a day

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