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Further research is also needed to determine the variability of different populations (based on characteristics such as age, sex, and pregnancy) affected by smoking, and the reasons for such differences in the development of effective treatments

Smoking interferes with each of these elements, which is why healing timelines for smokers are often longer than for non-smokers

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Clinicians consider smoking history when assessing HRT safety, often recommending transdermal routes and individualized care plans to balance symptom relief with cardiovascular and thromboembolic risk

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