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Abbreviations List BOE Biomarker of Exposure CDC Centers for Disease Control CPD Cigarettes Per Day FDA Food and Drug Administration HPHC Harmful and Potentially Harmful Constituent LOD Limit of Detection MEC Mobile Examination Center NHANES National Health and Nutrition Examination Survey PAH Polycyclic Aromatic Hydrocarbon TTFC Time to First Cigarette tNNAL Total NNAL VOC Volatile Organic Compound Footnotes Conflicts of Interest: The authors have no competing interests to declare

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It addresses misconceptions about their "natural" and "additive-free" marketing, explains the health risks associated with higher nicotine exposure, and discusses the shift to color-coded packaging after the FDA's ban on terms like "light" and "mild. Key Takeaways American Spirit cigarettes contain an average of 3.3 mg of nicotine per cigarette, higher than many popular US brands