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By mixing these dark, fermented pieces with other herbs or lighter tobaccos, the smoker can create a custom experience that is far more powerful than the sum of its parts

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The widest variation occurs in 1997, where the LOO range spans from -30.6 to -18.0 (a 12.6-pack spread), likely driven by removing Nevada (the second-largest weighted state)

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He said there was a real opportunity to minimise such harms by adapting the strategies that have proved to be effective in reducing smoking incidence and prevalence in the general population.

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