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7.2c Varenicline Varenicline is a partial agonist of the neuronal acetylcholine receptor subtype 42 and also functions as an agonist of dopamine turnover, ultimately reducing symptoms of nicotine withdrawal ( 87 )

It can also lead to lower bone density (brittle bones), which increases the risk of broken bones and fractures

These withdrawal symptoms make cessation difficult in the first couple weeks of cessation efforts

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Countries that signed on to the treaty agreed to protect their public health policies from the vested interests of the tobacco industry. This provision stemmed from a long history of tobacco giants around the world derailing anti-smoking measures by lobbying politicians, misleading them about the dangers of their products and orchestrating astroturfing campaigns to give the appearance of grassroots opposition to anti-smoking laws