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Fowles J and Dybing E

When consumed individually, drinking and smoking pose significant health risks

They concluded ECV can elevate level of damaged mitochondrial DNA in circulating blood and induce the expression of toll-like receptor 9 (TLR9), thereby increasing the expression of proinflammatory cytokines in monocyte/macrophage, which is responsible for atherosclerosis

The smoke also caused damage to the lungs and bladders of mice, indicating that it may increase the risks of developing lung and bladder cancer

This causes a persistent cough, as the lungs try to rid themselves of particulate matter, and makes smokers more susceptible to respiratory ailments