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NAPEPLD , DAGLA , DAGLB ) of key ligands, such as 2-arachidonoylglycerol (2-AG) and anandamide (AEA)

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The ICD-10-CM defines dependence as requiring behavioral indicators such as: Strong desire or compulsion to use the substance Difficulty controlling use Continued use despite harm Higher priority given to substance use than to other activities Evidence of tolerance or withdrawal (although not required for the uncomplicated specifier) The ICD 10 code for cannabis dependence, F12.20, is used when the criteria for dependence are present without physiological complications such as withdrawal or psychotic symptoms

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