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Erin and Jared NesSmith claimed their daughter became addicted to Juul e-cigarettes and suffered seizures

In the case of multiple waves of follow-up data, evidence of a positive baseline e-cigarette use by time interaction term for either smoking status, frequency, or intensity would indicate that e-cigarette use is associated with increased likelihood or speed of progression in the respective outcome, whereas a negative interaction term would indicate that e-cigarette use is associated with reduced likelihood or speed of progression

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doi:10.1038/s41370-022-00449-2

With these initiatives, [our] Japanese domestic tobacco business will be able to develop insight into consumers needs and promptly respond to their changes