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The mechanisms by which tobacco smoke worsens outcomes remain unclear but may include tumour hypoxia, altered drug metabolism, stimulation of signalling pathways by nicotine and changes to the immune system, including reduced natural killer cells, the authors noted

2007, 7 (147): 75- Freeman B, Chapman S, Rimmer M: The case for the plain packaging of tobacco products

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Big Tobacco will argue that the ban violates their trademarks and seizes their intellectual property, and they may find a few sympathetic judges