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in 2020, it was responsible for 161,853 deaths (13% of the total) [4] and economic costs exceeding 125 billion reais

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Spontaneous rupture of large arteries was not observed at all and, in particular, neither in the 6 patients with the COL1A1 p.(Arg312Cys) missense variant nor in 2 individuals with different COL5A1 glycine substitutions at the C-terminal domain (Additional Table 1), which represent variants previously associated with a possible higher risk of vascular events [16]

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For any retailer that violates the e-cigarette law, the department can impose a penalty of $1,000 per violation and refer the matter to the city attorneys office, which can institute civil proceedings and potentially layer on civil penalties of up to $1,000 per violation

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