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According to the CDC, tobacco use is the leading preventable cause of death in the United States, and it estimates more than 5 million people will die worldwide this year from tobacco-related ailments, including cancer, heart attacks, strokes and other diseases

In studies involving overweight and obese patients with type 2 diabetes who were on various oral diabetes medications, the combined therapy of naltrexone and bupropion frequently led to ADRs such as nausea, constipation, vomiting, and diarrhea (Wharton et al., 2021)