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Cell death signaling including cleaved caspase-3 was enhanced, the anti-apoptotic BAX was reduced, and the pro-apoptotic BCL-2 was elevated [114]

Young peoples usage rates reported by countries tracking this issue as diverse as the UK, Poland, New Zealand and Korea suggest a small incidence of regular use but doubling or tripling adolescent use year on year [4],[5],[6],[7]

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